Although no clear mechanism has been described, certain genetic and environmental factors have been suggested for etiopathogenesis. It is generally seen in male patients in older age, but atypical cases in different age groups have been documented.
Remitting seronegative symmetrical synovitis with pitting edema ( RS 3 PE syndromeĭirectory of Open Access Journals (Sweden)įull Text Available Remitting seronegative symmetrical synovitis with pitting edema is a rare rheumatological disorder that presents with symmetrical hand and/or foot edema resembling rheumatoid arthritis. Corticosteroid should be tapered off cautiously in patients with RS 3 PE syndrome.
However, two patients showed a deteriorated clinical condition during the tapering of corticosteroid. Treatment with corticosteroid was very effective in all cases. All cases shared common clinical findings, such as acute onset, symmetrical polyarthritis, pitting edema of the hands and feet, and being negative for rheumatoid factor in serum. It is important to be aware of RS 3 PE syndrome when encountering elderly patients with polyarthritis who are negative for rheumatoid factor. RS 3 PE syndrome (Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome) is one of the disorders which present as polyarthritis. Nakajima, Naoya Fukuda, Yukiko Yang, Kwang-Seok Aiba, Miyoji Tsuda, Hiroshi International Nuclear Information System (INIS) Four therapeutic cases of RS 3 PE syndrome
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